The « INTERTOX » project
INTERTOX is a project that brings together the excellence and expertise of multiple teams at CentraleSupélec and Gustave Roussy, particularly in the fields of complex and innovative predictive modelling, breast cancer survivorship, ethics, and psychology. These expertises are all aligned on the common aim of improving the after-cancer experience and particularly of understanding and communicating the risk of cancer-related toxicities and how they affect patients' lives. INTERTOX has two main Aims. Aim 1: Identify trajectories and bio-behavioral risk factors of distressing toxicities and quality of life (QOL) degradation after breast cancer; Aim 2: Determine how to effectively communicate risk of distressing toxicities and degradation of QOL to patients, paving the way for the implementation and utilization of the models developed during Aim 1 in clinical practice. For Aim 1, the project will build on a) a quantitative strategy to construct predictive risk models -taking advantage of clinical, biological, and patient-reported outcome data from the CANcer TOxicities [CANTO] cohort-, but also on b) the iterative input of social and human science experts. For Aim 2, a qualitative study to understand how to communicate the results of the models developed by Aim 1 to patients will be implemented. Aim 2 will use a cutting-edge digital infrastructure, weSHARE.
Antonio DI MEGLIO
Patenaires liés à Paris-Saclay
- CentraleSupélec, Lab MICS
- INSERM Unit 981, Gustave Roussy
- CESP (Inserm, UPSay, UVSQ)
- Gustave Roussy
Autres partenaires et partenaires étrangers
Shoshana Rosenberg, BA, MPH, ScD, Harvard Medical School, focused on breast cancer survivorship, quality of life, and treatment decision-making, including decision aids.
Dr. Rosenberg will co-mentor one of the post-doctoral researchers (N. 2): expertise in research dedicated to the improvement of care for women with breast cancer (e.g., qualitative analyses in psychosocial studies, focused on quality of life and cancer) contributing to the development of aim 2.